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Activase rt-pa has been related to the side effect of Obtundation. If you are taking Activase rt-pa and have experienced Obtundation this information may be of use to you.  
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Activase rt-pa Drug Insert (if available)
IMPORTANT NOTE: The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.
Activase rt-pa Ingredients
  • Alteplase
  • Tissue plasminogen activator (recombinant)
    • Activase rt-pa - Obtundation Outcomes
  • Died drug may be contributory - 1 Reported Cases
    • Activase rt-pa - Obtundation Involvements
  • Suspected - 1 Reported Cases
    • Other Reactions Reported While Taking Activase rt-pa
    haemorrhage intracranial - 47 Reports cerebral haemorrhage - 30 Reports efficacy, lack of - 24 Reports angioedema - 21 Reports
    death - 14 Reports haemorrhage nos - 13 Reports hypotension - 13 Reports tongue oedema - 13 Reports
    myocardial infarction - 12 Reports headache - 7 Reports rash - 6 Reports vomiting - 6 Reports
    stroke - 6 Reports unconsciousness - 5 Reports urticaria - 5 Reports cardiac arrest - 5 Reports
    chest pain - 5 Reports haematoma - 5 Reports convulsions - 5 Reports nausea - 4 Reports
    bradycardia - 4 Reports oedema mouth - 4 Reports anaphylaxis - 4 Reports cardiac tamponade - 4 Reports
    consciousness decreased - 4 Reports oedema cerebral - 4 Reports haematuria - 4 Reports haemorrhage brain stem - 4 Reports
    cerebral infarction - 4 Reports thrombocytopenia - 3 Reports myocardial rupture (post infarct) - 3 Reports injection site bleeding - 3 Reports
    hemiplegia - 3 Reports numbness - 3 Reports haemorrhage cerebellar - 3 Reports lips swelling non-specific - 3 Reports
    anaphylactic reaction - 3 Reports haemoglobin decreased - 3 Reports thrombosis coronary - 3 Reports pallor - 3 Reports
    anaphylactoid reaction - 2 Reports respiratory disorder - 2 Reports allergic reaction - 2 Reports bruise - 2 Reports
    st elevated - 2 Reports fibrillation ventricular - 2 Reports tachycardia ventricular - 2 Reports haemorrhage retroperitoneal - 2 Reports
    vomiting blood - 2 Reports itching - 2 Reports pain - 2 Reports tongue swelling non-specific - 2 Reports
    feeling unwell - 2 Reports diaphoresis - 2 Reports aphasia - 2 Reports creatine kinase increased - 2 Reports
    hemiparesis - 2 Reports melaena - 2 Reports multiple organ failure - 2 Reports pruritus - 1 Reports
    rash maculo-papular - 1 Reports paralysis - 1 Reports speech disorder - 1 Reports embolism - blood clot - 1 Reports
    ataxia - 1 Reports dizziness - 1 Reports suicide attempt - 1 Reports abdominal pain - 1 Reports
    spleen disorder - 1 Reports shock cardiogenic - 1 Reports paresis - 1 Reports respiratory arrest - 1 Reports
    stupor - 1 Reports coma - 1 Reports emesis - 1 Reports temperature changed sensation - 1 Reports
    shivering - 1 Reports tongue inflammation - 1 Reports ventricular fibrillation paroxysm - 1 Reports pupillary reflex impaired - 1 Reports
    prothrombin time prolonged - 1 Reports fibrinogen plasma increased - 1 Reports exophthalmos - 1 Reports ocular haemorrhage - 1 Reports
    vision decreased - 1 Reports extrasystoles - 1 Reports blood in urine - 1 Reports fibrillation atrial - 1 Reports
    oral haemorrhage - 1 Reports breathing difficult - 1 Reports nasal congestion - 1 Reports hoarseness - 1 Reports
    erythema - 1 Reports hot dry skin - 1 Reports renal failure acute - 1 Reports livedo reticularis - 1 Reports
    neuritis - 1 Reports angina pectoris - 1 Reports congestive heart failure - 1 Reports muscle stiffness - 1 Reports
    slurred speech - 1 Reports atrial flutter/ fibrillation - 1 Reports haematemesis - 1 Reports pulmonary oedema - 1 Reports
    crackles - 1 Reports cholesterol blood excessive - 1 Reports indigestion - 1 Reports oedema periorbital - 1 Reports
    face oedema - 1 Reports eyelid oedema - 1 Reports blindness temporary - 1 Reports eruption - 1 Reports
    embolism cerebral - 1 Reports subdural haematoma - 1 Reports dyspnoea - 1 Reports fatigue extreme - 1 Reports
    cpk increased - 1 Reports confusion - 1 Reports mobility decreased - 1 Reports vasospasm - 1 Reports
    thrombosis - 1 Reports gingival bleeding - 1 Reports thrombosis venous deep - 1 Reports sepsis - 1 Reports
    condition aggravated - 1 Reports brain stem infarction - 1 Reports vitreous haemorrhage - 1 Reports sputum bloody - 1 Reports
    retrosternal pain - 1 Reports anginal pain - 1 Reports pulmonary haemorrhage - 1 Reports sinus tachycardia - 1 Reports
    tachypnoea - 1 Reports hypertension - 1 Reports bronchopneumonia - 1 Reports strabismus - 1 Reports
    numbness localized - 1 Reports lethargy - 1 Reports obtundation - 1 Reports haemorrhage pharyngeal - 1 Reports
    ldh increased - 1 Reports gastrointestinal tract bleed nos - 1 Reports laryngeal oedema - 1 Reports stridor - 1 Reports
    pulse rate decrease marked - 1 Reports ecg abnormal - 1 Reports
    Activase rt-pa Uses

    Activase rt-PA - definition of Activase rt-PA in the Medical ...
    Actilyse (UK), Activase, Activase rt-PA (CA), Cathflo Activase, Lysatec rt-PA (CA) ... Off-label uses ? Blocked venous catheter (2-mg bolus injected into catheter for ...

    Cathflo Activase - definition of Cathflo Activase in the Medical ...
    Actilyse (UK), Activase, Activase rt-PA (CA), Cathflo Activase, Lysatec rt-PA (CA) ... Off-label uses ? Blocked venous catheter (2-mg bolus injected into catheter for ...

    IV vs. IA tPA (Activase) in Acute Ischemic Stroke With CTA Evidence of ...
    ... is by administration of recombinant tissue plasminogen activator or Activase (Alteplase, rt-PA ... Molecular Mechanisms of Pharmacological Action: Therapeutic Uses: Hematologic Agents

    Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute ...
    ... combination of two drugs--integrilin (eptifibatide) and activase (recombinant tissue plasminogen activator, rt-PA ... Therapeutic Uses: Hematologic Agents: Nervous System Diseases

    Alteplase (20:12.20) - 389001
    Other Uses. rt-PA has been used for lysis of subocclusive intracoronary thrombi in a small ... by intracatheter instillation into occluded central venous catheters (Cathflo ® Activase ® ...

    General Information on Activase rt-pa related to Obtundation

    Tufts Medical Center - TPA Protocol
    Institute for Clinical Research and Health ... Coma, or severe obtundation. ... If Activase is mixed and then not used, return to Pharmacy as there is a buy ...

    Acute stroke thrombolysis with intravenous tissue plasminogen activator ...
    obtundation with fixed eye deviation and complete hemiplegia or NIHSS score >22) ... ders and Stroke rt-PA Stroke Study Group. N Engl J. Med 1995; 333: 1581-1587. ...

    eMJA: Acute stroke thrombolysis with intravenous tissue plasminogen ...
    ... National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. ... MD, Buchan AM. The Canadian Activase for Stroke Effectiveness Study (CASES) ...

    Stroke citation list for mesh topheading 'Thrombolytic Therapy'
    Sonothrombolysis in acute ischemic stroke for patients ineligible for rt-PA. ... patient with a cerebellar stroke, leading to obtundation during elective cardiac ...

    Stroke citation list for mesh topheading 'Thrombolytic Therapy' and ...
    Sonothrombolysis in acute ischemic stroke for patients ineligible for rt-PA. ... patient with a cerebellar stroke, leading to obtundation during elective cardiac ...
    Activase rt-pa Settlements
    Activase rt-pa Interactions

    eMedicine - Pulmonary Embolism : Article by Craig Feied, MD, FACEP ...

    ... or aneurysm; known bleeding diathesis; severe uncontrolled hypertension Interactions ... performed 4 h after initiation of fibrinolytic therapy Drug Name Alteplase (rt-PA, Activase ...

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    The New England Journal of Medicine C o py r ig ht © 2 0 0 2 by t he Ma s s ac h u s e t t s Me d ic a l S o c ie t y V O L U M E 3 4 7
    Activase rt-pa Recalls

    Canadian Adverse Reaction Newsletter, Volume 9, Issue 3, July 1999
    Advisories, Warnings & Recalls. Canadian Adverse Reaction Newsletter (CARN) Consultations ... Alteplase (Activase® rt-PA) for acute ischemic stroke ...

    NEUROBIOLOGICAL TECHNOLOGIES INC /CA/
    File type:PDF - Download PDF Reader
    which markets Activase (alteplase), or rt-PA, the only currently ... letters, product recalls or seizures, total or partial suspension of production ...

    Neurobiological Technologies, Inc. - Annual Report
    which markets Activase ® (alteplase), or rt-PA, the only currently approved drug ... recalls or seizures, total or partial suspension of production or distribution, ...

    Neurobiological Technologies, Inc. - Annual Report
    which markets Activase, or rt-PA, the only currently approved drug treatment for ... withdrawal of an approval, a clinical hold, warning letters, product recalls ...

    Canadian Adverse Reaction Newsletter, Volume 10, Issue 2, April 2000
    Advisories, Warnings & Recalls. Canadian Adverse Reaction Newsletter ... alteplase (Activase® rt-PA) bupropion (Zyban®, Wellbutrin SR®) celecoxib (CelebrexTM) ...
    Activase rt-pa Side Effects
    Obtundation - Activase rt-pa Remedies